You've probably read about the recent Case and Deaton paper about the increase in the death rate among middle-aged white Americans. Andrew Gelman at Columbia has a very interesting further analysis of the data and his conclusion is that the uptrend is solely in the women:
Since 2005, the death rate has been rising for middle-aged white women and declining for middle-aged white men. Not by a lot—we’re talking a change of 4% over a decade—but this is what we see.
Comments by John Thacker suggest that this might be explained by smoking.