"Is tech talent acquisition a huge problem in San Francisco?"

A Security Engineering Manager at Google thinks so:

Top tech talent that is already in the Bay Area is pretty much guaranteed to be in a great role already. People do change jobs occasionally but basically the talent pool is tapped out. So that means recruiting someone from outside. You know what makes a crappy recruiting pitch? 10% income tax, $3000/month rent for 1 bedroom, and 90 minute commutes. California's restrictions on guns are also a deal breaker for a nontrivial number of people. When you can live in Seattle instead and work for an equally good company with no income tax, $2000 rents and 30 minutes commutes, the Bay Area looks like a terrible deal. This is a big reason Seattle is once again the nation’s fastest-growing big city, growing 3 times faster than San Francisco, and why Google is expanding faster outside the Bay Area than inside it.[1]

"The epic mistake about manufacturing that’s cost Americans millions of jobs"

I don't know if the thesis advanced here is correct, but I do know that there can be big surprises when you disaggregate data.

Between 2000 and 2016, the average growth in the sector’s real output was only about 63% of that of the private sector. But when you take out computers out of both data series, the trend is far more striking: Since 2000, manufacturing output expanded at an average pace equal to only 12% of the private sector’s average growth.