I missed this last year. Terrific story.
His name is Jack Andraka, and he loves science and engineering with every inch of his 15-year-old soul. Just spend a minute or so watching this video. Seriously, do it now before you read more. Nothing from the Oscars or Grammys comes close to the unabashed excitement and joy of Andraka charging up to the stage to accept his $75,000 grand prize at the Intel International Science and Engineering Fair in May. This is theOlympics of youth science, with more than 1,500 entries from 70 countries competing, each of which already won their national competitions. . . .
A nanotube sensor with a targeted antibody is extremely sensitive. In a single-blinded test of 100 patient samples, Andraka’s sensor spotted the presence of mesothelin, a protein commonly used as a biomarker for pancreatic cancer, at a limit of 0.156 nano grams per milliliter, well below the 10 ng/mL considered an overexpression of mesothelin consistent with pancreatic cancer. It’s also 100 times more selective than existing diagnostic tests, which means no false positives or false negatives. It ignored healthy patient samples as well as those with mere pancreatitis. Compared with the 60-year-old diagnostic technique called enzyme-linked immunosorbent assay (or ELISA), used in pregnancy test strips and viral checks for HIV, West Nile and hepatitis B, Andraka’s sensor is 168 times faster, 26,667 times less expensive, and 400 times more sensitive. It can spot the presence of the cancer-linked protein well before the cancer itself becomes invasive. This could save the lives of thousands of pancreatic cancer victims each year. The sensor costs $3 (ELISA can cost up to $800) and ten tests can be performed per strip, with each test taking five minutes. It can be used also to monitor resistance to antibiotics and follow the progression of treatment of cancer patients undergoing chemotherapy or radiation.